منابع مشابه
Genetic causes of human heart failure.
Factors that render patients with cardiovascular disease at high risk for heart failure remain incompletely defined. Recent insights into molecular genetic causes of myocardial diseases have highlighted the importance of single-gene defects in the pathogenesis of heart failure. Through analyses of the mechanisms by which a mutation selectively perturbs one component of cardiac physiology and tr...
متن کاملUnusual causes of heart failure.
A DISCOURSE oni unusual eauses of heart failure naturally follows and overlaps any discussion on unusual causes of heart disease, aiid some repetition is unavoidable. However, one outstanding distinction is that in which the normal heart fails on exposure to a gross overload, as for example after the production of a large aortic-caval fistula such as has followed operation for an intervertebral...
متن کاملGenetic causes of spermatogenic failure.
Approximately 10%-15% of couples are infertile, and a male factor is involved in almost half of these cases. This observation is due in part to defects in spermatogenesis, and the underlying causes, including genetic abnormalities, remain largely unknown. Until recently, the only genetic tests used in the diagnosis of male infertility were aimed at detecting the presence of microdeletions of th...
متن کاملHeart failure: be aware of reversible causes.
Sir, Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. There is wide recognition that AF is an important risk factor for thromboembolic events, particularly stroke. A less well-recognized (but nonetheless important) consequence of prolonged and usually unrecognized AF is left ventricular dysfunction, which resolves with treatment of the atrial fibrillation. A 50-year-old...
متن کاملI-41: Genetic Causes of Premature Ovarian Failure (POF) and early Menopause
Premature ovarian failure (POF) is a heterogeneous disorder, defined as menopause under age 40 years. The prevalence is 1%; POF before age 30 years is much less common. Chromosomal causes have long been recognized - visible deletions of the X chromosome, 45,X/46,XX mosaicism, and autosomal rearrangements (balanced translocations). Toxins or iatrogenic causes (e.g., chemotherapeutic agents) are ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2005
ISSN: 0021-9738
DOI: 10.1172/jci24351